Alternate Name: Berberine Hydrochloride, Berberine HCl
Specification: 97% Berberine HCl
Appearance: Yellow crystalline powder
Extraction Part: Bark, Root
Test Method: HPLC
Sample: 10-50g Sample For free
MOQ: 1kg
Certificate: ISO22000, Kosher, Halal, Organic(EU), USDA, FSSC 22000, FDA,SGS
OEM Service: Private label and Customized package
Hydrochloride Berberine Powder, also referred to as Berberine HCl or Berberine Hydrochloride, is a bioactive alkaloid extracted from plants like Berberis species. Its main functional component, berberine hydrochloride, is widely studied for supporting metabolic balance, glucose regulation, and cardiovascular wellness, making it a versatile ingredient in dietary supplements and functional formulations.
In the current market, high-quality Berberine HCl is in growing demand, with manufacturers and supplement brands seeking consistent purity, reliable supply, and customizable options. Variations in raw material sources often lead to inconsistencies in potency and solubility, creating challenges for brand formulations.
At Botanical Cube Inc., our Hydrochloride Berberine Powder stands out for its high purity and stable bioavailability, produced under strict quality controls with multiple certifications to ensure safety and compliance. Beyond providing bulk supply, we specialize in tailored OEM solutions, offering flexible formulation guidance, private labeling, and packaging options that allow brands to efficiently bring products to market. Our deep experience in Berberine HCl ensures not just a product, but a reliable ingredient partnership built for scalability and performance.
1. High Purity ≥97% (HPLC Verified) – Ensures consistent potency and reliable performance in formulations.
2.Optimized Particle Size – 100% passing 80 mesh, improving blend uniformity and solubility for solid or liquid products.
3. Near-20 Years of Production Expertise – Decades of experience in Berberine HCl extraction and processing reduce batch variability.
4. OEM & Formulation Support – Guidance on solubility, blending, and technical troubleshooting to shorten R&D cycles.
5. Custom Packaging & Documentation – Tailored packaging and COAs/Regulatory support for smooth product launch.
| Test Item | Specification | Result |
| Appearance | Yellow to light yellow powder | Light yellow powder |
| Assay (Berberine HCl, HPLC) | ≥97.0% | 97.30% |
| Loss on Drying | ≤5.0% | 3.20% |
| Residue on Ignition | ≤0.5% | 0.20% |
| Particle Size | 100% pass 80 mesh | 100% pass 80 mesh |
| Heavy Metals (Pb, As, Cd, Hg) | Pb ≤2ppm, As ≤1ppm, Cd ≤1ppm, Hg ≤0.1ppm | Pb 0.8ppm, As 0.3ppm, Cd 0.2ppm, Hg <0.1ppm |
| Microbial Limits | Total Plate Count ≤1000 CFU/g, Yeast & Mold ≤100 CFU/g, E. coli Negative, Salmonella Negative | Total Plate Count 120 CFU/g, Yeast & Mold 25 CFU/g, E. coli Negative, Salmonella Negative |
| Solubility | Soluble in water & ethanol | Pass |
| pH (1% solution) | 4.0 – 6.0 | 5.2 |
| Identity (UV/HPLC) | Positive | Pass |
| Ash Content | ≤0.5% | 0.30% |
1. Particle Size Control
Uniform mesh (e.g., 80–100 mesh) ensures homogeneous mixing and predictable dissolution.
2. Moisture Control
Maintain ≤5% moisture to prevent caking and degradation.
3. Purity & Heavy Metals
Routine HPLC and ICP testing ensures ≥97% berberine content, with heavy metals below international limits.
4. Microbial Safety
Regular microbial testing guarantees compliance with USP/EP microbial limits, minimizing formulation risk.
5. Process Optimization
Use optimized extraction, drying, and milling techniques refined through nearly 20 years of experience, reducing batch variability.
1. Dietary Supplements
Supports glucose metabolism, cardiovascular health, and weight management; often formulated as capsules, tablets, or soft gels.
2. Functional Beverages & Drinks
Integrated into wellness drinks, protein shakes, and herbal infusions for metabolic support.
3. Nutraceutical Blends
Combined with chromium, alpha-lipoic acid, cinnamon extract, or other botanical extracts to enhance synergistic effects on blood sugar and energy metabolism.
4. Herbal Formulations
Used in combination with turmeric, green tea, or ginseng for comprehensive metabolic support.
1. Capsules/Tablets
200–500 mg per serving, 1–3 servings per day depending on regulatory guidelines and formulation goals.
2. Functional Beverages
100–300 mg per serving, with solubility enhancers or flavor masking as needed.
Tips: Dosage must consider combined active ingredients to maintain stability and efficacy.
Q: How soluble is Berberine HCl?
A: Moderate water solubility. Optimizing particle size, pH adjustment, or using mild heat can improve dispersion.
Q: Can it be combined with other botanical extracts?
A: Yes, but check for pH interactions and avoid highly acidic or alkaline environments to prevent degradation.
Q: How to mask bitter taste in beverages or chewables?
A: Consider microencapsulation, coating, flavor masking agents, or sweeteners for palatable formulations.
Q: Stability concerns?
A: Stable in dry, cool storage; avoid moisture, high heat, or long-term exposure to light.
Q: Is there batch-to-batch consistency?
A: Our production ensures ≥97% assay, controlled particle size, and consistent bioavailability, reducing variability in formulations.
Our Hydrochloride Berberine Powder combines ≥97% assay, fine particle control, and high stability, specifically tailored for supplement and functional product manufacturers who demand consistent ingredient performance. With nearly 20 years of production and R&D experience, we provide OEM solutions that cover formulation guidance, taste masking strategies, custom packaging, and regulatory documentation support. Certified under cGMP, ISO, and HACCP, our powder helps brands reduce variability and accelerate product launch timelines. Connect with us to build a trusted ingredient partnership: info@botanicalsuppliers.com.
Just send email to info@botanicalsuppliers.com, or submit your requirement in bottom form, we are of service at any time!
If you have any questions, please contact our experts.We are always ready to help you with individual formulations, private label solutions or any other requirements to kick-start your brand!