Product Name:Vitamin K2 MK4 Powder
Other Name:Menaquinone-4
Specification:0.2%、0.5%、1.3%、98%
Appearance:Light Yellow Powder
Cas No:863-61-6
Grade:Food Grade
MOQ:1KG
Sample:5-50g Sample For free
OEM:Customized order packaging and labels; OEM capules and pills
Certificate:Kosher, Halal, EU, USDA, HACCP, FSSC 22000, Organic
Vitamin K2 is a fat-soluble vitamin with a menaquinone structure, of which MK4 (menaquinone-4) is a subtype of Vitamin K2. The chemical name of MK4 is menaquinone-4, which is different from other vitamin K2 subtypes in side chain structure. This structural difference gives it some unique properties and physiological functions. When supplementing MK4, factors such as individual age, gender, and health status need to be considered.
Sources: MK-4 is primarily found in animal-based foods, such as chicken, egg yolks, and certain dairy products. It is also produced in the body from vitamin K1.
Functions: It is vital for blood clotting and is essential for bone health, including bone density and structure. It also supports cardiovascular health by helping to manage calcium deposits.
Half-life: MK-4 is a short-chain version of vitamin K2, meaning it is cleared from the body more quickly compared to other forms like MK-7.
| Product Name | Vitamin K2 MK4 Powder |
| Other Name | Menaquinone-4 |
| CAS No. | 863-61-6 |
| Appearance | Light Yellow Powder |
| Specification | 0.2%、0.5%、1.3%、98% |
| Test | HPLC |
| Grade | Food grade |
| COA | Avaialble |
| Certificate | Kosher, Halal, EU, USDA, HACCP, FSSC 22000, Organic,FDA,QS |
| Sample | 5-50g Sample For free |
| MOQ | 1kg |
| OEM Service | OEM bag/bottle is available with private label.OEM capules andtablets. |
| Packaging | 1kg/bag/carton or 25 kg/drum or carton or Customers’ Requirement |
| Shelf life | 2 year,Available InBulk, Private Label/OEM, Individually Packaged Goods |
Vitamin K2 as MK-4 supports bone health by helping calcium bind to bones, which can reduce fractures and improve bone density. It also benefits cardiovascular health by preventing calcium from building up in arteries and promoting arterial flexibility. Other benefits include potential anti-inflammatory effects and supporting cognitive function, although more research is needed in these areas.
Bone strength: Activates proteins like osteocalcin to help bind calcium to the bone matrix, which strengthens bones and can reduce the risk of fractures. It is even used as a treatment for osteoporosis in Japan.
Osteoporosis prevention: May help prevent bone loss and fractures in various conditions, such as postmenopausal osteoporosis and bone loss from corticosteroids.
Dental health: Low levels of vitamin K2 are linked to periodontal diseases, suggesting a role in maintaining dental health.
Prevents arterial calcification: Activates proteins like Matrix Gla Protein (MGP) to help prevent calcium from depositing in arteries, which can lead to hardening of the vessels.
Improves arterial flexibility: Helps prevent the stiffening of arteries, which is important for healthy blood flow and can help prevent high blood pressure and other heart-related conditions.
Anti-inflammatory effects: Vitamin K2 exhibits anti-inflammatory properties, which may help with overall immune health.
Cognitive function: May help protect the nervous system from damage caused by calcium deposits, potentially supporting cognitive function in older adults.
Cancer prevention: Some studies suggest it may play a role in preventing certain cancers, though more research is required.
Vitamin K2 is a family of fat-soluble vitamins, with MK-4 and MK-7 being two of its most common forms. The primary differences lie in their chemical structure, bioavailability, and half-life: MK-7 is a long-chain menaquinone with a long half-life and excellent bioavailability, allowing for once-daily supplementation, while MK-4 is a short-chain form that is cleared from the body more quickly and requires a higher dose, taken multiple times a day.
Vitamin K2 MK-7
Structure: A long-chain menaquinone.
Half-life: Long, measured in days, allowing for once-daily intake.
Bioavailability: Highly bioavailable, which means it stays in the bloodstream longer and can be efficiently used by the body.
Absorption: Better absorbed and results in sustained higher serum concentrations for several days.
Dosing: Typically requires a lower daily dose, such as 120mcg or more, taken once daily.
Vitamin K2 MK-4
Structure: A short-chain menaquinone.
Half-life: Short, measured in hours, necessitating more frequent doses.
Bioavailability: Poor bioavailability compared to MK-7; its absorption does not lead to increased or sustained serum concentrations.
Absorption: Quickly disappears from the circulation.
Dosing: Requires a much higher dosage, such as 45mg (45,000 mcg), taken multiple times a day.
Both Vitamin K2 as MK-4 and MK-7 are nearly completely absorbed, with peak serum concentration at 2 hours for MK-4 and 4 hours for MK-7 after intake. However, MK-4 quickly disappears from the circulation, whereas MK-7 is capable of accumulating in the bloodstream (remaining in the body for approximately 72 hours).
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